GLP-1 Agonists Explained: Semaglutide, Tirzepatide & Retatrutide

Ozempic. Wegovy. Mounjaro. Zepbound. These names are everywhere right now — and for good reason. GLP-1 agonists are the most effective weight loss drugs we’ve ever had. But there’s a lot of confusion out there. Let’s clear it up. What Are GLP-1 Agonists? GLP-1 (glucagon-like peptide-1) is a hormone your body naturally produces after eating. It does a few things: Signals fullness — tells your brain you’re satisfied Slows stomach emptying — food stays in your gut longer Increases insulin release — helps regulate blood sugar Decreases glucagon — reduces sugar release from your liver GLP-1 agonists are drugs that mimic this hormone, but they’re much more powerful and last much longer than your natural GLP-1. ...

January 26, 2026 · 6 min · Dr. Tanner Mobley, MD